GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs801193 | 1 | rs10252765 | chr7:66228732 | TYW1 | chr7:66461817-66704496:+ | 0.15 | 4.13 | 3.99E-5 | Aortic root size |
| BRCA | cis | rs10256972 | 1 | rs10256972 | chr7:1039003 | ZFAND2A | chr7:1192544-1199855:- | 0.36 | 10.21 | 2.02E-23 | Longevity;Endometriosis |
| BRCA | cis | rs10270805 | 1 | rs10270805 | chr7:16500142 | ISPD | chr7:16127152-16460947:- | -0.23 | -3.44 | 0.000614 | Response to statin therapy |
| BRCA | cis | rs718314 | 1 | rs1027087 | chr12:26470850 | BHLHE41 | chr12:26272961-26278003:- | 0.13 | 3.64 | 0.000288 | Waist-hip ratio;Renal cell carcinoma |
| BRCA | cis | rs718314 | 1 | rs1027087 | chr12:26470850 | SSPN | chr12:26348269-26405853:+ | 0.11 | 3.6 | 0.000333 | Waist-hip ratio;Renal cell carcinoma |
| BRCA | cis | rs7794364 | 1 | rs10270960 | chr7:117525639 | CTTNBP2 | chr7:117350708-117513561:- | -0.14 | -4.26 | 2.18E-5 | Idiopathic osteonecrosis of the femoral head |
| BRCA | cis | rs801193 | 1 | rs10274773 | chr7:66133578 | CRCP | chr7:65579805-65619551:+ | 0.13 | 3.38 | 0.000758 | Aortic root size |
| BRCA | cis | rs801193 | 1 | rs10274773 | chr7:66133578 | TYW1 | chr7:66461817-66704496:+ | -0.15 | -4.02 | 6.33E-5 | Aortic root size |
| BRCA | cis | rs848490 | 1 | rs10279537 | chr7:77474961 | PHTF2 | chr7:77428109-77586818:+ | -0.15 | -4.43 | 1.06E-5 | Glomerular filtration rate (creatinine);Glomerular filtration rate in non diabetics (creatinine) |
| BRCA | cis | rs12196860 | 1 | rs1028390 | chr6:55935791 | COL21A1 | chr6:55921389-56258892:- | -0.38 | -6.94 | 6.82E-12 | Psychosis (atypical) |
| BRCA | cis | rs2286503 | 1 | rs1029740 | chr7:22873586 | TOMM7 | chr7:22852254-22862421:- | -0.15 | -4.88 | 1.22E-6 | Fibrinogen |
| BRCA | cis | rs5743030 | 1 | rs1030136 | chr2:190735660 | ORMDL1 | chr2:190634994-190649097:- | 0.22 | 3.69 | 0.000238 | Subcutaneous adipose tissue |
| BRCA | cis | rs1030420 | 1 | rs1030420 | chr8:67360725 | C8orf46 | chr8:67405491-67430757:+ | 0.16 | 3.96 | 7.94E-5 | Blood metabolite levels |
| BRCA | cis | rs6452524 | 1 | rs1031902 | chr5:82448127 | XRCC4 | chr5:82373317-82649577:+ | -0.12 | -3.56 | 0.00038 | Hypertension |
| BRCA | cis | rs738722 | 1 | rs1033667 | chr22:29130300 | HSCB | chr22:29138043-29153488:+ | 0.12 | 3.48 | 0.000522 | Esophageal cancer and gastric cancer |